Clinical significance of SUMO4 expression in papillary thyroid carcinoma
10.3969/j.issn.1000-4718.2015.08.013
- VernacularTitle:SUM O4在甲状腺乳头状癌中的表达及临床意义
- Author:
Qinyan SHEN
;
Huihui WU
;
Jinxiao LIANG
;
Jinye XU
;
Yong LIANG
- Publication Type:Journal Article
- Keywords:
Smallubiquitin-relatedmodifier4;
Papillarythyroidcarcinoma;
Immunohistochemistry
- From:
Chinese Journal of Pathophysiology
2015;(8):1422-1426
- CountryChina
- Language:Chinese
-
Abstract:
AIM:Todiscusstherelationshipbetweensmallubiquitin-relatedmodifier4(SUMO4)expression and papillary thyroid carcinoma (PTC).METHODS:The mRNA and protein levels of SUMO4 in PTC and normal thyroid tissues were determined by the methods of real-time PCR, Western blot and immunohistochemistry .The relationship be-tween SUMO4 expression and clinicopathologic parameters in PTC was evaluated .RESULTS:The results showed that both the mRNA and protein levels of SUMO 4 expression in PTC were obviously higher than those in normal thyroid tissues ( P<0.01).CONCLUSION:The high level of SUMO4 expression in PTC suggests that SUMO4 plays an important role in PTC development and it is probably a molecular mechanism of PTC .
