Ultrastructural changes and significance of endometriotic rat model with HCG treatment
10.3969/j.issn.1000-4718.2015.08.030
- VernacularTitle:HCG 治疗子宫内膜异位症大鼠模型的超微结构变化及意义
- Author:
Lingling WU
;
Yuzhu YIN
;
Ke SUN
;
Jinlang WU
;
Hongying HOU
- Publication Type:Journal Article
- Keywords:
Endometriosis;
Humanchorionicgonadotropin;
Ultrastructure
- From:
Chinese Journal of Pathophysiology
2015;(8):1516-1519
- CountryChina
- Language:Chinese
-
Abstract:
AIM:Toinvestigatewhetherandhowhumanchorionicgonadotropin(HCG)treatmentameliorates endometriosis in the endometriotic rat model .METHODS:The rat model of endometriosis was established and the model rats were divided into 4 groups.The rats in HCG groups were treated with 19.4, 25.8 and 51.6 IU/100 g of HCG every day (low-dose HCG, medium-dose HCG and high-dose HCG, respectively).The rats in control group were treated with 0.9%NaCl.After 15 days (3 estrous cycles), the ectopic lesion volume and ultrastructural characteristics in eutopic and ectopic endometria were investigated .RESULTS: After HCG treatment , the volume of endometriotic lesions was signifi-cantly smaller than that before treatment .Numerous and mitochondrial , endoplasmic reticulum and ribosomes were ob-served in the cytoplasm of eutopic and ectopic endometrium before treatment .After treatment , some cell structures were not clear , and mitochondrial cristae decreased or disappeared partly .Some cells were densed and shrinkage , autophagosome in cytoplasm increased , and mitochondria and endoplasmic reticulum swelt .CONCLUSION:HCG therapy appears to be an effective treatment for endometriosis in rats attributed to its influence on cell metabolism dysfunction of eutopic and ectopic endometria .
