Regulatory effect of miRNA enfolded in microparticles on endothelial cells
10.3969/j.issn.1000-4718.2015.08.033
- VernacularTitle:细胞微泡 miRNA 对内皮细胞的调控
- Author:
Qianhao LI
;
Honggang ZHANG
- Publication Type:Journal Article
- Keywords:
Microparticles;
MicroRNA;
Endothelial cells
- From:
Chinese Journal of Pathophysiology
2015;(8):1531-1536
- CountryChina
- Language:Chinese
-
Abstract:
Endothelialcellsarethecellsliningtheinnersurfacesofbloodvessels.Theybuildupasinglecell layer and play an important role in the regulation of vascular functions and the maintenance of homeostasis .The activation or injury of endothelial cells is associated with multiple diseases , including hypertension , atherosclerosis, cancer, diabe-tes, etc.Recent studies have found that microparticles are involved in the process of endothelial cell injury , thus playing a part in the development of many diseases .miRNAs enfolded in the microparticles have become importance in recent years . Moreover , recent studies also found that the concentration of the miRNAs enfolded in the microvesicles is higher than that of the miRNAs in the plasma , which means that the microparticles are the main form of miRNAs present in peripheral circula -tory system.This article is to review the recent research progress in microparticle-encapsulated miRNAs and their regulatory effect on endothelial cell injury .
