The effect of Xuebijing injection on transfusion and inflammatory factors in patients with traumatic coagulopathy
10.3969/j.issn.1006-5725.2015.20.042
- VernacularTitle:血必净注射液对创伤性凝血病患者血制品输注及炎症因子的影响
- Author:
Mingyuan MA
;
Haobo JIANG
;
Yunhai ZHANG
;
Menghua DENG
;
Na YU
;
Zhenhong QI
- Publication Type:Journal Article
- Keywords:
Xuebijing injection;
Traumatic coagulophathy;
Transfusion;
Inflammation
- From:
The Journal of Practical Medicine
2015;(20):3415-3418
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Xuebijing injection on transfusion and systemic inflammation in traumatic coagulopathy patients. Methods Seventy-nine patients were randomly divided into Xuebijing Group (36 cases) and Control Group (43 cases). Xuebijing group received Xuebijing injection in addition to the regular treatment received by control group. Levels of TNF-α, IL-6, IL-8 and transfusion amount between two groups were compared. Results Coagulation abnormality was almost corrected in all patients after treatment. In Xuebijing Group, transfusion of RBC, FFP and cryoprecipitate were significantly less than that in control group (P<0.05). At 72 h after admission, TNFα, IL-6 and IL-8 were significantly lower in Xuebijing Group (P < 0.05). Conclusion Xuebijing injection could reduce transfusion in traumatic coagulopathy patients , possibly resulting from its antagonism against systemic inflammation.
