Intestinal Absorption of Nicorandil in Rats
10.3870/j.issn.1004-0781.2015.11.008
- VernacularTitle:尼可地尔在大鼠小肠吸收研究
- Author:
Min FENG
;
Juan DU
;
Ning LIN
- Publication Type:Journal Article
- Keywords:
Nicorandil;
Small intestinal absorption;
Absorption Kinetics;
Chromatography,high performance liquid
- From:
Herald of Medicine
2015;(11):1448-1450
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the absorption properties and kinetics of nicorandil from small intestinal segments. Methods The absorption kinetics and permeability of nicorandil under different conditions were investigated by HPLC via the in situ perfusing method in rats. Results There was no significant difference in Ka of nicorandil under different concentrations and different pH.The absorption rate in rats descended in order of jejunum,duodenum,ileum and colon, as (4.69±0.05)×10-2 ,(3.35 ±0.04) × 10-2 ,(2.66± 0.05) × 10-2 and (0.89± 0.08) × 10-2 .h-1 . Conclusion The absorption of nicorandil in intestine complies with the passive transport mechanism and first order kinetics.Nicorandil is well absorbed in the whole intestine and can be prepared as delayed release and controlled release forms.
