Mechanisms of lung injuries exposed to sulfur mustard:recent advances
10.3867/j.issn.1000-3002.2015.05.064
- VernacularTitle:芥子气肺损伤机制研究进展
- Author:
Xiaoji ZHU
;
Shuangshuang ZHU
;
Yuxu ZHONG
- Publication Type:Journal Article
- Keywords:
sulfur mustard;
inflammatory reaction;
oxidative stress;
apoptosis;
DNA damage
- From:
Chinese Journal of Pharmacology and Toxicology
2015;(5):859-864
- CountryChina
- Language:Chinese
-
Abstract:
Sulphur mustard (SM) is a corrosive alkylating agent that is likely to be absorbed in vivo through the lungs,eyes and skin into internal organs. SM not only can produce its peculiar cytotoxic?ity thought to be mediated by the alkylation of DNA,protein and nucleic acids,but is a strong mutagen and carcinogen. However,whatever the way SM poisoning occurs,lungs are the most vulnerable, and early death is mainly carused by both the acute respiratory distress syndrome and pulmonary infec?tion. In this review,we analyzed SM-induced lung injury mechanisms.
