The significance of serum homocysteine and neutrophil gelatinase associated lipocalin detection in patients with hypertensive nephropathy
10.3969/j.issn.1673-4130.2015.20.019
- VernacularTitle:高血压肾病患者血清同型半胱氨酸及中性粒细胞明胶酶相关脂质运载蛋白检测的意义
- Author:
Duan CHEN
- Publication Type:Journal Article
- Keywords:
hypertensive nephropathy;
homocysteine;
neutrophil gelatinase-associated lipocalin;
urinary albumin excretion rate
- From:
International Journal of Laboratory Medicine
2015;(20):2967-2968
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the clinical significance of serum homocysteine(Hcy) and neutrophil gelatinase‐associated li‐pocalin(NGAL) in patients with hypertensive nephropathy ,and explore the relationship between serum homocysteine ,NGAL con‐centration and Urinary albumin excretion rate(UAER) .Methods 103 patients with hypertension treated in renal and cardiovascular department of Huangshi Central Hospital from January 2012 to June 2014 were enrolled in the study and were divided into 3 groups :macroalbuminuria group (36 cases) ,microalbuminuria group (35 cases) and negative albuminuria group (32 cases) .In addi‐tion to that ,33 healthy people were recruited as control group .Serum homocysteine ,NGAL concentration and UAER were meas‐ured for the peple enrolled in the study .Results Serum homocysteine and NGAL concentration of macroalbuminuria group and mi‐croalbuminuria group were much higher than negative albuminuria group and control group(P<0 .05) .Serum homocysteine and NGAL concentrations compared between macroalbuminuria group and microalbuminuria group were significantly different (P<0 .05) .Serum homocysteine and NGAL concentrations of negative albuminuria group and control group were not significantly dif‐ferent(P>0 .05) .UAER was positively correlated with serum homocysteine and NGAL concentration(r=0 .792 ,0 .658 ,P<0 .05) . Conclusion The detection of serum homocysteine and NGAL are helpful in understanding the changes of disease in patients with hypertensive nephropathy .
