Application Progress in CFTR Inhibitors in the Treatment of Secretory Diarrhea
- VernacularTitle:囊性纤维化跨膜传导调节因子抑制药在分泌性腹泻中的应用研究进展
- Author:
Qianqian XU
;
Yubo WANG
;
Yanping WANG
;
Shijin GUO
;
Zhimei ZHANG
;
Zhiqiang SHEN
- Publication Type:Journal Article
- Keywords:
CFTR inhibitors;
Secretory diarrhea;
Thiazolidinone;
Glycine hydrazides;
Quinoxalinediones;
Effective components in natural plants
- From:
China Pharmacist
2015;(8):1378-1382
- CountryChina
- Language:Chinese
-
Abstract:
Secretory diarrhea provides a major health challenge worldwide, which is one of the most important reasons for children morbidity and death. The activation of Cl- channels in intestinal epithelial cells resulting in the excessive fluid secretion in the intestine is the main reason of diarrhea caused by enterotoxins. In diarrhea caused by cholera and the other bacterial enterotoxins, cystic fibrosis transmembrane conductance regulator ( CFTR) is the main cAMP-control Cl- channel to promote the fluid secretion in epithelial cells. Therefore, CFTR inhibitors are the new choices for secretory diarrhea. CFTR inhibitors include thiazolidinone, glycine hydrazide and quinoxalinedione chemical classes, and some components from natural plants also exhibit CFTR inhibition activity, however, further studies should be done.
