Effect of laser combined with intravitreal administration of bevacizumab on patients with diabetic retinopathy
10.3969/J.ISSN.1672-8270.2015.08.031
- VernacularTitle:激光联合贝伐单抗玻璃体腔注射治疗糖尿病视网膜病变的临床疗效观察
- Author:
Chun ZHENG
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Bevacizumab;
Laser
- From:
China Medical Equipment
2015;(8):98-101
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze Effect of laser combined with intravitreal administration of bevacizumab on patients with diabetic retinopathy.Methods: Chose 106 cases of diabetic retinopathy patients between June 2012 to June 2014 in our hospital as research object, according to stochastic indicator method divided into observation group (53cases) received laser combined with intravitreal administration treatment, control group(53cases) treated with bevacizumab administration alone,compared two groups of patients with visual acuity and retinal thickness,serum level of VEGF and Ang-2,serum levels of oxidative stress indicators.Results: 1)Observation group patients’ visual acuity level was obviously higher than that of control group, retinal thickness was significantly lower than control group(t=5.375,t=6.839;P<0.05); 2)Observation group patients serum VEGF and Ang-2 levels were significantly lower than control group(t=8.842, t=9.742;P<0.05); 3)Observation group patients adiponectin,superoxide dismutase(sod) levels were higher than control group, malondialdehyde level was lower than control group(t=7.382,t=8.276,t=6.093;P<0.05).Conclusion:Laser combined with intravitreal administration therapy can improve patients' eyesight, decrease thickness of retina, inhibit angiogenesis and optimize systemic oxidatie stress levels.
