Effect of high dose metformin on serum HE4, LPA and regulatory T cells in patients with ovarian cancer
- VernacularTitle:大剂量二甲双胍对卵巢癌患者血清HE4、LPA与Tr的影响研究
- Author:
Yu HUANG
;
Nian YANG
;
Fei ZHOU
- Publication Type:Journal Article
- Keywords:
metformin;
ovarian cancer;
HE4;
LPA;
regulatory T cells
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(7):76-78
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis the effect of high dose metformin on serum HE4, LPA and regulatory T cells in patients with ovarian cancer.Methods 80 cases of unilateral ovarian cancer patients were given surgery and conventional chemotherapy ,were divided into four groups according to single metformin dose: (group A:0.25g each time, B group:0.25g each time, group C:0.25g each time; group D: conventional treatment only) and three times a day oral administration of metformin and two weeks in a row , before and after the treatment of detection each serum HE4, LPA, transformation growth factor beta 1 (TGF -beta 1), interleukin -10 (IL-10) content, and CD4 +CD25 +CD127 regulating T cell percentage.ResuIts Compared with B, C, and D group, the efficacy of patients in group A was better, as follows: Serum HE4 content decreased significantly ( P<0.05 ); serum LPA content decreased significantly ( P<0.05 ); blood CD4 +CD25 +CD127 regulatory T cell percentage decreased significantly ( P<0.05 ); serum TGF beta 1, IL-10 content decreased significantly ( P<0.05 ) .The results were statistically significant .ConcIusion High dose of metformin can reduce serum HE4 , LPA content, reduce the adjusting the percentage of T cells and related cytokines in patients with ovarian cancer , and play a positive role in inhibit cancer cell proliferation and invasion .
