Effects of curcumin on NT-pro-BNP, IL-6, IL-10 and pulmonary function in patients with sepsis induced by lung injury
- VernacularTitle:姜黄素对脓毒症肺损伤患者血清NT－pro－BNP、IL－6、IL－10及肺功能影响研究
- Author:
Lihua ZHANG
;
Tielin ZHANG
;
Jin DU
;
Jingguo ZHANG
- Publication Type:Journal Article
- Keywords:
curcumin;
lung injury;
BNP NT-Pro;
IL-6;
IL-10;
lung function
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(7):89-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of curcumin on NT-pro-BNP, IL-6, IL-10 and pulmonary function in patients with sepsis induced by lung injury.Methods 40 patients with purulent septic lung injury were collected in the hospital and divided into control group and experimental group according to different treatment, 20 cases in each group.The control group were given conventional treatment and the experimental group were given curcumin capsule on the basis of control group for a consecutive treatment of one weeks.After treatment, the serum levels of NT-pro-BNP, IL-6, IL-10 and pulmonary function were detected of two groups.ResuIts Compared with control group after treatment, serum IL-6 and IL-10 levels of patients in experimental group decreased significantly ( P<0.05 ) , serum NT-pro-BNP levels in experimental group decreased significantly ( P<0.05 ) , vital capacity (VC), maximal voluntary ventilation (MVV), and forced expiratory volume in one second (FEV1) levels in experimental group increased significantly (P<0.05).ConcIusion Curcumin could significantly reduce serum NT-pro-BNP, IL-10 and IL-6 levels in patients with lung injury, improve the pulmonary function, and has a guiding significance for clinical use.
