Effect of matrine on sex hormone level, metal ion content and soluble tumor necrosis factor receptor in male patients with liver cirrhosis
- VernacularTitle:苦参碱辅助治疗对男性肝硬化患者性激素水平、金属离子含量及可溶性肿瘤坏死因子受体的影响
- Author:
Yanling LI
;
Yufeng ZHAI
;
Huaihong ZHANG
;
Xiuming HEI
- Publication Type:Journal Article
- Keywords:
matrine;
liver cirrhosis;
sex hormone;
metal ion;
soluble tumor necrosis factor receptor
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(7):98-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the effect of matrine on sex hormone level, metal ion content and soluble tumor necrosis factor receptor in male patients with liver cirrhosis.Methods 70 cases male patients diagnosed with liver cirrhosis of decompensation period were selected in the hospital and randomly divided into experimental group and control group, 35 cases in each group.The experimental group were treated with 250 mL matrine sodium chloride injection on the basis of conventional treatment and the control group were given equal 0.9%sodium chloride injection, once a day, intravenous drip for a consecutive treatment of 4 weeks.The liver function, sex hormone levels, metal ion content, and soluble tumor necrosis factor receptor indicators were detected before and after treatment in two groups.ResuIts Compared with control group, serum liver enzymes and total bilirubin in experimental group decreased (P<0.05);the content of serum testosterone increased and estradiol levels decreased (P<0.05);serum zinc, iron and magnesium content increased, manganese content decreased (P<0.05); serum soluble tumor necrosis factor receptor levels decreased (P<0.05). ConcIusion Matrine adjuvant therapy could regulate the level of sex hormone and metal ion in male patients with liver cirrhosis, reduce the level of soluble tumor necrosis factor receptor, improve liver function in patients with cirrhosis.
