Effect of folic acid combined with Qizhi Weitong granule on serum gastrin, sIL-2 R and immune function in chronic atrophic gastritis patients of Hp positive
- VernacularTitle:叶酸联合气滞胃痛颗粒对Hp阳性慢性萎缩性胃炎患者血清胃泌素、sIL－2 R及免疫功能影响
- Author:
Chunyu KONG
;
Mei WU
;
Zhaoyong LI
- Publication Type:Journal Article
- Keywords:
folic acid;
Qizhi Weitong granule;
chronic atrophic gastritis;
gastrin,sIL-2R;
immune function
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(7):101-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate folic acid combined with Qizhi Weitong granule on serum gastrin, sIL-2R and immune function in chronic atrophy gastritis patients of Hp positive.Methods 46 cases with Hp positive chronic atrophy gastritis were selected and randomly divided into two groups according to different treatment, 23 cases in each group.The control group were given folic acid tablet on the basis of conventional treatment, and the experimental group were treated on the basis of control group combined with Qizhi Weitong granule.The patients in two groups were all treated for three months.Serum gastrin, sIL-2R and T cell subsets levels were detected after treatment.ResuIts Compared with control group after treatment, the serum gastrin level of experimental group was higher (P<0.05), sIL-2R level was lower (P<0.05), CD4 +T, CD4 +T/CD8 +T were higher (P<0.05), and CD8 +T level was lower ( P<0.05 ) .ConcIusion Folic acid combined with Qizhi Weitong granule could significantly increase serum gastrin and CD4 +T level and reduce sIL-2R and CD8 +T level in chronic atrophy gastritis patients of Hp positive, as a guidance for clinical.
