Effect of breviscapine on serum copeptin, NT-proBNP, HIF-1αand IMA in patients with acute ischemic cere brovascular disease
- VernacularTitle:灯盏花素对急性缺血性脑血管病患者血清copeptin、NT－proBNP、HIF－1α及IMA影响研究
- Author:
Xinjian MA
;
Lianwei LU
;
Liling GAO
- Publication Type:Journal Article
- Keywords:
breviscapine;
acute ischemic cerebrovascular disease;
copeptin;
NT-proBNP;
HIF-1α
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(7):119-121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis effect of breviscapine on serum and copeptin, NT-proBNP, HIF-1αand IMA in patients with acute ischemic brain vascular disease.Methods 42 patients who were diagnosed with acute ischemic brain vascular disease were collected and randomly divided into experimental group and control group, each group had 21 cases.All patients were given conventional treatment of Western medicine, on this basis, control group was given vinpocetine injection 20 mg, once daily intravenous drip;experimental group given Dengzhan flower Suting injection 20 mg, once daily intravenous drip; continuous treatment for 2 weeks.Before and after the treatment, the serum levels of copeptin, HIF-1α, NT-proBNP and IMA were detected in two groups.ResuIts Compared with control group, patients in experimental group treatment effect was better, as follows: serum copeptin content decreased significantly ( P<0.05 ) .Serum NT-proBNP levels decreased significantly ( P<0.05 ) .Serum levels of HIF-1αcontent decreased significantly (P<0.05).Serum ACB value increased significantly (P<0.05).ConcIusion Breviscapine can reduce the acute ischemic brain vascular disease patients serum copeptin, NT-proBNP, HIF-1αand IMA content, and has good therapeutic effect in patients with acute ischemic cerebral vascular disease.
