USP inhibitors and screening methods
- VernacularTitle:泛素特异性蛋白酶抑制剂及其筛选方法
- Author:
Feiyang JI
;
Hongrui LI
;
Weilin CHEN
- Publication Type:Journal Article
- Keywords:
ubiquitin;
deubiquitination;
ubiquitin-specific protease;
inhibitor;
drug screening
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(7):152-156
- CountryChina
- Language:Chinese
-
Abstract:
The ubiquitin-specific protease ( USP) inhibitors influence many crucial cellular activities and some immune processes, such as anti-inflammatory, anti-infection and anti-tumor by silencing the functions of USP.The main USP inhibitors, which potency and specificity are underlined and current methods for detecting and identifying USP inhibitors are discussed of in this review.
