Progress on relationship between occurrence, development of colon cancer and molecular mechanism of miRNA
- VernacularTitle:结肠癌发生、发展与miRNA分子机制相关研究进展
- Author:
Weidong WANG
;
Yusong YUAN
;
Qin HE
- Publication Type:Journal Article
- Keywords:
colon cancer;
miRNA;
molecular mechanism
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(7):169-171
- CountryChina
- Language:Chinese
-
Abstract:
miRNA ( microRNA) is a small molecule, which is composed of about 20 nucleotides, and has been a hot research topic in recent years.Many studies indicated that the expression level of miRNA in tumor changed, which played a role in the differentiation and proliferation of tumor cells, as a function of oncogene or tumor suppressor gene.The occurrence and development of colon cancer is related to the abnormal expression of many genes, and the data shows that the abnormal expression of miRNA is closely related to the development of colon cancer.In this paper, the influence of miRNAs on the development of colon cancer and its relevant mechanism were collected, then the colon cancer occurrence, development and miRNA molecular mechanisms were studied, which provided a theoretical basis for the molecular target treatment of colon cancer.
