Discordances between interpretation algorithms for genotypic resistance in prediction of human immunodeficiency virus resistance
- VernacularTitle:不同基因型耐药分析系统在HIV耐药预测中的应用
- Author:
Tianyi HAO
;
Qi GUAN
;
Lining WANG
- Publication Type:Journal Article
- Keywords:
human immunodeficiency virus;
genotypic resistance;
interpretation analysis system
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(7):182-184
- CountryChina
- Language:Chinese
-
Abstract:
As highly active anti-retroviral therapy continues, large numbers of drug-resistant strains appeared in human immunodeficiency virus ( HIV) infectors, which always leads to a decline of treatment results or even a treatment failure.The genotypic resistance analysis technique of the bioinformatics is a powerful tool to forecast the HIV resistance and also determines the success or failure of antiviral therapy.This review will be focus on the advantages and disadvantages, influence factor of the genotype resistance prediction and improve measure of the primary HIV drug resistance genotype interpretation system, depending on the principle and characteristics of the genotypic drug resistance analysis as the breakthrough point, in order to provide guidance for reasonable application of different genotypes drug resistance analysis system in China.
