Preparation and properties of drug carrier non-PEG blank liposomes
- VernacularTitle:药物载体非PEG空白脂质体的制备及稳定性研究
- Author:
Mengjuan YUAN
;
Jun HAN
- Publication Type:Journal Article
- Keywords:
non-PEG blank liposomes;
high pressure homogeneous method;
extrusion method;
ultrasonic method
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(7):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare drug carrier non-PEG blank liposomes, and study its properties.Methods High purity of egg yolk lecithin and cholesterol were used as film forming material.The high pressure homogeneous method-extrusion method and high pressure homogeneous method-ultrasonic method were used to prepare non-PEG blank liposomes.After that how the method of high pressure homogeneous, extrusion and ultrasonic influence the particle size of blank liposomes were studied, and the physical stability of blank liposomes were investigated.ResuIts The particle size of blank liposomes prepared by high pressure homogeneous method-extrusion method was about 86 nm, and its polydispersity index was 0.170.While the particle size of the blank liposomes prepared by high pressure homogeneous method-ultrasonic method was about 91 nm, and its polydispersity index was 0.362.ConcIusion Compared with high pressure homogeneous method-ultrasonic method, the blank liposomes prepared by high pressure homogeneous method-extrusion method had some advantanges, such as smaller particle size, narrow particle size distribution and high stability.
