Effect of Rho kinase combined with Sheng Mai injection on TNF-α, IL-10, ICAM-1 and CD11/CD18 in patients with Ⅱ°superficial burn
- VernacularTitle:Rho激酶联合生脉注射液对浅二度烧伤患者外周血TNF－α、IL－10、ICAM－1及CD11／CD18水平影响
- Author:
Guanjun XIANG
;
Hongzheng YANG
;
Jing HUANG
;
Yizhi PENG
- Publication Type:Journal Article
- Keywords:
Rho kinase;
Sheng Mai injection;
Ⅱ°superficial burn;
tumor necrosis factor alpha;
interleukin-10;
intercellular adhesion molecule-1;
CD11/CD18
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(7):57-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of Rho kinase combined with Sheng Mai injection on tumor necrosis factor alpha ( TNF-α) , interleukin-10 (IL-10), intercellular adhesion molecule-1 (ICAM-1) and adhesion molecule CD11/CD18 in patients withⅡ°superficial burn.Methods 48 cases patients withⅡ°superficial burn were collected and divided into experimental group and control group, according to different therapy, 24 cases in each group.The two groups were given symptomatic treatment such as anti-infectious, keep warm, anti-shock, pain-relieve and wound-healing treatment, the control group were given Rho kinase on the basis of symptomatic treatment, and experimental group were given Sheng Mai injection on the basis of control group, for a course of two weeks.The serum TNF-α, IL-10, ICAM-1 and CD11/CD18 levels were compared after treatment. ResuIts After treatment, the serum TNF-α, IL-10, ICAM-1 and CD11/CD18 levels after treatment were lower than those before treatment in two groups (P<0.05).Compared with control group, the levels of TNF-α, IL-10, ICAM-1 and CD11/CD18 were lower than those of experimental group (P<0.05).ConcIusion Rho kinase combined with Sheng Mai injection could significantly reduce the levels of TNF-α, IL-10, ICAM-1 and CD11/CD18 in patients with Ⅱ°superficial burn.
