Distribution characteristics of NPC1L1 gene 1 735 C>G polymorphism and relationship between serum lipid levels and obesity in Guangxi Han population
10.3969/j.issn.1671-8348.2015.24.010
- VernacularTitle:广西汉族人群 NPC1L1基因1735 C>G 多态性分布特征及与血脂、肥胖的关系?
- Author:
Lin MIAO
;
Ruixing YIN
;
Dongfeng WU
- Publication Type:Journal Article
- Keywords:
polymorphism,single nucleotide;
dyslipidemias;
niemann-pick c1-like 1;
body mass index
- From:
Chongqing Medicine
2015;(24):3341-3344
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the distributional characteristics of NPC1L1 1 735 C>G polymorphism and the relation-ship between serum lipid levels and obesity in Guangxi Han population.Methods Genotyping of the NPC1L1 1 735 C>G poly-morphism of 409 cases of Han was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis in all subjects.The relationship of different genotypes in blood lipid levels and obesity were evaluated.Re-sults The frequency of CC,CG and GG genotypes was 39.40%,46.00% and 14.60% in Han.The frequency of C and G alleles was 62.35% and 37.65% in Han.The levels of BMI,LDL-C,ApoB was different among the three genotypes (P <0.05).The G al-lele carriers had higher serum LDL-C and ApoB levels than the G allele noncarriers (P <0.05 ).Serum lipid parameters and BMI were also correlated with some environmental factors.Conclusion The 1 735 C>G polymorphism in NPC1L1 gene may be correla-ted with serum lipid profiles and obesity,the G allele might increase the risk of hyperlipemia and obesity.
