Effects of baicalin on the expression of TAFI,NF-κB,and ACE2 in the atherosclerotic rats
10.3969/j.issn.1671-8348.2015.24.008
- VernacularTitle:黄芩苷对动脉粥样硬化模型大鼠 NF-κB TAFI 及 ACE2表达水平影响
- Author:
Minghui BI
;
Cheng CHENG
;
Peng LI
;
Pingsheng WU
- Publication Type:Journal Article
- Keywords:
baicalin;
atherosclerosis;
NF-κB;
TAFI;
ACE2
- From:
Chongqing Medicine
2015;(24):3334-3336
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of baicalin on the expression of TAFI,NF-κB,and ACE2 in the atherosclerotic rats and discuss the anti-atherosclerosis mechanisms of baicalin.Methods The subjects were healthy male Wistar rats.The rats were divided into sham operation group,model group,baicalin high dose group (1 50 mg·kg-1 ·d-1 )and baicalin low dose group (100 mg·kg-1 ·d-1 ).Plasma TAFI activity were detected with enzymatic assays.The expression of NF-κB and ACE2 were detec-ted with immunohistochemical staining.Results Compared with sham group,the rest groups of TAFI and ACE2 activity were sig-nificantly higher (P <0.05),and the expression of NF-κB,had significant decreased (P <0.05).Compared with the model group, the level of TAFI and ACE2 in baicalin drug group was significantly lower than the model group (P <0.05),and the expression of NF-κB,had significant increased.Conclusion Baicalin can reduce TAFI and ACE2 level,and upregulate the expression of NF-κB to play its role in anti atherosclerosis.
