Radiosensitization effect of tetrandrine on advanced non-small-cell lung cancer
10.3969/j.issn.1671-8348.2015.24.018
- VernacularTitle:汉防己甲素对晚期非小细胞肺癌的放疗增敏作用
- Author:
Wei XIAO
;
Mei HONG
- Publication Type:Journal Article
- Keywords:
tetrandrine;
carcinoma,non-small-cell lung;
radiotherapy;
paclitaxel
- From:
Chongqing Medicine
2015;(24):3362-3364
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the radiosensitization effects of tetrandrine on advanced non small cell lung cancer and its toxicity.Methods The patients of 82 cases with advanced non-small cell lung cancer were confirmed by pathology or cytology.The first course of treatment was treated with radiation therapy.Patients were divided into three groups:tetrandrine group,paclitaxel group and radiotherapy group.Tetrandrine group(30 cases)took radiotherapy with 40 mg tetrandrine(3 times a day)from the first day to the ending.Paclitaxel group (29 cases)took radiotherapy with intravenous infusion of 60 mg paclitaxel(once a week).Radio-therapy group (23 cases)only received radiotherapy.Results Tetrandrine and paclitaxel had the same radiosensitizing effect in ra-diotherapy.The total effective rate of tetrandrine and paclitaxel group was higher than radiotherapy group (P <0.05 ).The inci-dence of radiation pneumonitis in tetrandrine group was significantly lower than the other two groups (P <0.05).The one year free disease survival rate was promoted in tetrandrine group than other groups.Conclusion Tetrandrine was known as the same radia-tion sensitizing effect of paclitaxel fairly,which can reduce the toxicity of radiotherapy.
