Preparation optimization of palonosetron hydrochloride oral disintegrating tablets by orthogonal test
10.3969/j.issn.1671-8348.2015.24.027
- VernacularTitle:正交试验优化盐酸帕洛诺司琼口腔崩解片的制备工艺
- Author:
Fengyun LIN
;
Yi LUO
;
Jiefang YANG
- Publication Type:Journal Article
- Keywords:
prescriptions,drug;
pharmaceutical preparations;
palonosetron hydrochloride;
orally disintegrating tablets;
direct compression process;
disintegration time;
dissolution
- From:
Chongqing Medicine
2015;(24):3393-3395
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare optimization of palonosetron hydrochloride oral disintegrating tablets by orthogonal test. Methods Palonosetron hydrochloride oral disintegrating tablets were prepared with direct compression process.The content of pal-onosetron hydrochloride was determined by HPLC.The formulation was optimized with disintegration time as evaluation indices. Results The optimal formulation(60 mg/tablet)was as follows:L-HPC 12%,mannitol∶SMCC= 2∶1,magnesium stearate 2%, stevia glycosides 3%.The oral disintegrating tablets showed dine appearance and tested better;the disintegration time was 12 sec-onds;the tablets featured a hardness of 3 kg;4 min dissolution rate was 99%.Conclusion The preparation method is simple and reasonable,and the tablets can disintegrate rapidly.
