The comparative study of deficit/non-deficit schizophrenia serum proteins
10.3969/j.issn.1673-4130.2015.15.002
- VernacularTitle:缺陷型／非缺陷型精神分裂症患者血清蛋白表达谱的比较研究
- Author:
Hui DONG
;
Keming ZHU
;
Xiaowei TANG
;
Xiaobin ZHANG
- Publication Type:Journal Article
- Keywords:
deficit schizophrenia;
serum;
proteomics
- From:
International Journal of Laboratory Medicine
2015;(15):2131-2132
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore differently expressed proteins in serum samples obtained from Deficit Schizophrenia as well as Non‐Deficit Schizophrenia patients with proteomic techniques .Methods Make the comparative study of serum proteins between DS and NDS patients with two‐dimensional electrophoresis .The screened proteins were identified by mass spectrometer .Results Dur‐ing 18 differently expressed protein points screened in this study ,15 proteins were identified by mass spectrometer .Among of them , 12 proteins are up‐regulated while 3 proteins are down‐regulated in DS patients group .Conclusion It′s the first time to make the comparative study of serum protein profiles between DS and NDS patients by proteomic analysis .We expect that this study will contribute to better understanding of the pathophysiology of DS and explore the potential disease‐associated biomarker ,improve the future study for clinical medication of schizophrenia .
