Related factors of no or weak immune response after inoculation of hepatitis B vaccine
10.3969/j.issn.1673-4130.2015.15.020
- VernacularTitle:成人接种乙肝疫苗后无、弱免疫应答的相关因素
- Author:
Jianbo ZHANG
;
Wenbo LUO
;
Shunying HUANG
;
Weimin HUANG
;
Fengjuan CHEN
- Publication Type:Journal Article
- Keywords:
hepatitis B;
immune response;
hepatitis B vaccine
- From:
International Journal of Laboratory Medicine
2015;(15):2172-2174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the related factors of no or weak immune response after inoculation of hepatitis B vaccine .Meth‐ods 120casesofadultreceivedinoculationofhepatitisBvaccineinourhospitalwereenrolled,including60casesofnoweakre‐sponse and 60 cases of normal response ,they were divided into non response group and response group .Related factors of no or weakimmuneresponsewereanalyzed.Results (1)singlefactoranalysis:Therewerestatisticalsignificanceofage,gender,BMI, smoking history ,HBV potential infection ,CD4+ T cells and CD8+ T cell content ,IFN‐γand IL‐2 content between two groups ;(2) logistic regression analysis :old age ,male ,smoking history ,high values of BMI ,HPV latent infection ,low content of CD4+ T cells and IFN‐γand IL‐2 ,high content of CD8+ cells were risk factors of no or weak immune response after inoculation of hepatitis B vaccine .Conclusion No or weak immune response after inoculation of hepatitis B vaccine is affected by gender ,age ,smoking ,obesi‐ty ,potential infection of HPV and immune function ,and necessary measure should be taken .
