Optimal dose research on manganese-enhanced MRI of rats optic nerve tracking

VernacularTitle:锰离子增强磁共振在大鼠视神经成像中剂量的合理选择
Author: Jun YANG ; Qinqing LI ; Chengde LIAO ; Yingying DING ; Dafu ZHANG ; Yusen FENG
Publication Type:Journal Article
Keywords: manganese ion; magnetic resonance imaging; optic nerve; concentration
From: Journal of Practical Radiology 2015;(8):1370-1373
CountryChina
Language:Chinese
Abstract: Objective To investigate the optimal concentration of manganese-enhanced MRI (MEMRI)in the visual pathway of experimental rats.Methods Sprague-Dawley rats were intravitreally injected with 3 μL of 10 - 100 mmol/L MnCl2 ,respectively. The contrast-to-noise ratio (CNR)of MEMRI for optic nerve(ON)and midbrain superior colliculus (SC)enhancement were measured at differ-ent concentrations of MnCl2 .Results The ON and SC were all clearly detected by MEMRI 24 h after unilateral intravitreal injected 10-100 mmol/L MnCl2 ,respectively.The CNR increased with the increasing concentration of MnCl2 from 10 to 50 mmol/L;But the CNR decreased from 50 to 100 mmol/L.The enhancement of superior colliculus were higher than optic nerve.Conclusion The optimal concentration of MnCl2 is 30 mmol/L(3 μL)through intravitreal injection for the rat visual pathway on 1.5T MEMRI.