Establishment and analysis of reference intervals for thyroid tests in pregnant women
10.3969/j.issn.1673-4130.2015.20.039
- VernacularTitle:妊娠期甲状腺筛查项目参考区间制定与分析
- Author:
Qiujin SUN
;
Wei YAN
- Publication Type:Journal Article
- Keywords:
pregnancy;
thyroid hormone;
reference interval
- From:
International Journal of Laboratory Medicine
2015;(20):3013-3015
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the reference intervals of thyroid hormone levels fro the women in early ,middle and late preg‐nancy in the local area .Methods Through the strict screening for routine diagnosis of pregnant women who went to the hospital , we choose 420 women with 6-37 weeks of pregnancy and 120 non pregnancy women(control group) .Chemiluminescence was used to detect thyroid stimulating hormone(TSH) ,free thyroxine(FT4 ) ,total thyroxine(TT4 ) ,free triiodothyronine(FT3) ,total triiodo‐thyronine(TT3 ) for the pregnant women in early pregnancy(0-12 weeks) ,mid‐pregnancy(13-27 weeks) ,and late pregnancy(28-40 weeks) and women in control group .Using those data ,we established reference intervals of thyroid hormone and use bilateral limits P2 .5 - P97 .5 to represent .Results The differences of serum TSH ,FT4 ,TT4 ,TT3 concentration between pregnant group and control group were statistically significant(P<0 .05);while the difference of serum FT3 concentration between pregnant group and control group was not statistically significant(P=0 .79) .The concentration of TSH was not statistically significantly different in the mid‐pregnancy compared with late pregnancy(P=0 .933) ,the reference interval can be merged as 0 .56-3 .94μIU/mL .Conclu‐sion The establishment of normal reference interval of thyroid hormone concentration in different period of pregnancy respectively is conducive to the diagnosis and treatment of thyroid disease in pregnancy .
