Effect of ademetionine assisted therapy on serum transferrin, myocardial enzyme spectrum and bilirubin in icterus neonatorum
- VernacularTitle:腺苷蛋氨酸辅助治疗对新生儿黄疸患儿血清转铁蛋白、心肌酶谱及血清胆红素的影响
- Author:
Xiaoxi TIAN
;
Min ZHANG
- Publication Type:Journal Article
- Keywords:
ademetionine;
neonatal jaundice;
transferrin;
myocardial enzyme spectrum;
serum bilirubin
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):66-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ademetionine assisted therapy on transferrin ( TRF) , myocardial enzyme spectrum and bilirubin in serum of patients with icterus neonatorum.Methods 86 cases of neonatal jaundice in the hospital were randomly divided into two groups.43 cases in control group were treated with conventional therapy, 43 cases in experimental group were treated by ademetionine.Serum transferrin, myocardial enzymes, serum total bilirubin levels and clinical effects were compared pre-treatment and post-weat ment.ResuIts Compared with control group, the TRF level of experimental group was higher (P<0.05), the level of Aspartate transaminase (AST), lactate dehydrogenase (LDH), creatine kinase (CK), and CK-MB in experimental group were lower (P<0.05), the total bile acid (TBA), total bilirubin (TBIL) and direct bilirubin (DBIL) in experimental group were lower (P<0.05).The total effective rate in experimental group was significantly higher than that in control group (χ2 =8.53, P<0.05).ConcIusion Ademetionine assisted therapy has a good clinical curative effect and could effectively reduce serum TRF, DBIL and myocardial enzyme spectrum level, which has important significance in the treatment of neonatal jaundice.
