Effect of dual antiplatelet drugs on Fibulin-5, vWF and P-selection in serum of patients with acute cerebral infarction
- VernacularTitle:双联抗血小板药物对急性脑梗死患者血清中扣针蛋白5、管性血友病因子和P－选择素的影响研究
- Author:
Yulin WANG
;
Jing LIU
;
Xianggui LONG
;
Liyong YIN
;
Yajie ZHANG
;
Zhijie CUI
- Publication Type:Journal Article
- Keywords:
dual antiplatelet drugs;
acute cerebral infarction;
fibulin-5;
vWF;
P-selectin;
adverse reactions
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):78-80
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the effect of dual antiplatelet drugs on fibulin-5, vWF and P-selection in serum of patients with acute cerebral infarction.Methods Diagnosed 60 patients with acute cerebral infarction in our hospital and collected. All patients were randomly divided into experimental group and control group, 30 cases in each group.The control group was treated with conventional treatment and aspirin, and the experimental group was treated with clopidogrel on the basis of control group.After treatment, the serum levels of Fibulin-5, vWF, P-selection and adverse reactions were detected in all patients.ResuIts After treatment, compared with control group, the serum Fibulin-5 level was significantly lower in experimental group ( P<0.05 );the serum vWF level in experimental group was significantly lower ( P<0.05 );the serum P-selectin level in experimental group was significantly lower (P<0.05);there was no significant difference in the incidence of adverse reactions between two groups. ConcIusion Dual antiplatelet drugs can reduce serum vWF, P-selectin and fibulin-5 in serum of patients with acute cerebral infarction, adverse reactions do not significantly increase, have guiding significance to clinical application.
