Effect of rosiglitazone on serum HMGB1, TNF-αand Th1/Th2 in patients with lung injury induced by sepsis
- VernacularTitle:罗格列酮治疗对脓毒症肺损伤患者血清HMGB1、TNF－α及Th1／Th2影响研究
- Author:
Qiang LI
;
Jianshun WU
;
Hui LI
- Publication Type:Journal Article
- Keywords:
rosiglitazone;
sepsis;
lung injury;
HMGB1;
TNF-α;
Th1;
Th2
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):95-97
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of rosiglitazone on serum HMGB1,TNF-αand Th1/Th2 in patients with lung injury induced by sepsis.Methods 60 patients with sepsis lung injury in our hospital from August 2013 to August 2014, were randomly divided into experimental group and control group according to the medication methods, 30 cases in each group, control group was given conventional western medicine treatment, including intensive care, gastrointestinal decompression, fasting water, added blood volume, anti-inflammatory, maintenance of water and electrolyte balance, improve microcirculation, etc.On the basis of control group, experimental group was treated with rosiglitazone, two times per day, two weeks as a course of treatment.Serum HMGB1, TNF-α, Th1/Th2 were detected in 1, 3, 7, 14 days in all patients.ResuIts Compared with control group post-treatment,serum HMGB1,TNF-αand Th1/Th2 ratio were significantly decreased in the experimental group (P<0.05).ConcIusion Rosiglitazone can significantly reduce the levels of serum HMGB1,TNF-αand Th1/Th2.
