Expression and prognosis in patients with cerebral infarction blood precursor protein and β-tubulin
10.3760/cma.j.issn.1008-6706.2015.16.002
- VernacularTitle:脑梗死患者淀粉样前体蛋白和β-微管蛋白的表达及预后研究
- Author:
Xianhui SHI
;
Hong ZHAO
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Amyloid precursor protein;
β-microtubule protein;
Prognosis;
Joint detection
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(16):2404-2406
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of amyloid precursor protein and β-microtubule protein,and to study their clinical significance in patients with cerebral infarction.Methods 108 cases of acute cere-bral infarction as the observation group and 60 normal adults as the control group were collected in the study.The expressions of amyloid precursor protein and β-microtubule protein in different clinical characters were detected by western blot.Results The results of observation group [APP:(168.78 ±13.64)μg/L,β-tubulin:(124.64 ± 27.08)μg/L]were significantly higher than those in control group (t =22.81,P <0.01;t =21.08,P <0.01).Their expressions were correlated with CT scores and prognosis.Conclusion The higher expressions of amyloid precursor protein and β-microtubule protein may promote the occurrence and development in patients with cerebral infarction. The joint detection should be helpful to predict the prognosis and direct the treatment.
