To evaluate the efficacy and safety of human recombinant platelet hormone on chemotherapy -induced thrombocytopenia in leukemia
10.3760/cma.j.issn.1008-6706.2015.16.019
- VernacularTitle:重组人血小板生成素治疗急性白血病化疗后血小板减少症的疗效观察
- Author:
Xiuxiu FAN
;
Meiyun SU
- Publication Type:Journal Article
- Keywords:
Human recombinant platelet hormone (rhTPO);
Recombinant human interleukin -11 (rhIL -11);
Leukemia;
Chemotherapy;
Thrombocytopenia
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(16):2461-2463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy of recombinant human thrombopoietin (rhTPO)for the treat-ment of chemotherapy -induced thrombocytopenia with leukemia.And to explore its security.Methods 80 thrombo-cytopenia of acute leukemia after chemotherapy were selected.All patients were randomly divided into the research group and the control group according to the single and double of order registration number in clinic,40 cases in each group.The control group was treated with recombinant human interleukin -11 (rhIL -11),the research group was applied rhTPO treatment.The platelet (PLT)level of two groups,and other indicators of change were detected,and adverse reactions were observed.Results PLT resuming maximum value of the research group was (217.4 ±52.7) ×109 /L,which was significantly higher than the control group,the difference was statistically significant (t =15.63, P <0.05).The time of PLT recovery to 100 ×109 /L of the research group after chemotherapy was (15.6 ±3.6)d, which was significantly lower than the control group,the difference was statistically significant (t =10.72,P <0.05). The adverse reactions incidence of the research group was 12.5%,lower than 35.0% of the control group,the differ-ence was statistically significant (χ2 =9.87,P <0.05).Conclusion The treatment effect of RhTPO for thrombocy-topenia of the acute leukemia after chemotherapy is better than that of rhIL -11,can significantly improve the throm-bocytopenia,and has less adverse reaction and higher security.It is worthy of clinical popularization and application.
