Malondialdehyde and coenzyme Q10 in serum in diabetic leg ulcer
10.3760/cma.j.issn.1008-6706.2015.16.033
- VernacularTitle:糖尿病并发下肢溃疡患者血浆丙二醛和辅酶 Q10水平的变化及意义
- Author:
Wenli HAO
- Publication Type:Journal Article
- Keywords:
Diabetic complication;
Malondialdehyde;
Coenzyme Q10
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(16):2504-2506
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level of plasma malondialdehyde (MDA)and coenzyme Q10 (CoQ10)in patients with type 2 diabetes mellitus,diabetic leg ulcer(DLU).Methods The DLU group consisted of 15 patients with leg ulcers and type 2 diabetes mellitus (7 men and 8 women).The diabetes group consisted of 15 patients with type 2 diabetes mellitus (8 men and 7 women).Ten healthy individuals,age and sex matched with the patients,were used as a control group.Laboratory investigations in the form of glycosylated hemoglobin,plasma MDA and plasma CoQ10 were assessed for all patients and controls.Results The study revealed that in the diabetes group,especially in the DLU group,the MDA level [(7.07 ±3.15)μmol/L and (3.15 ±2.66)μmol/L]was signifi-cantly higher than control group [(4.28 ±0.41)μmol/L]and the index difference between them (F =104.675,P <0.01),while CoQ10 levels in the two groups data[(0.33 ±0.16)mg and (0.16 ±0.16)mg ]were significantly lower than the control group [(0.86 ±0.13)mg](F =46.709,P <0.05).Conclusion Type 2 diabetic patients, especially with DLU,are at increased risk of oxidative stress manifested by increased plasma MDA.