The differential diagnosis value of detection of platelet specific autoantibody on idiopathic thrombocytopenic
10.3969/j.issn.1673-4130.2015.15.004
- VernacularTitle:血小板特异性抗体联合检测在免疫性血小板减少症鉴别诊断中的价值
- Author:
Fang LI
;
Wenhua PIAO
;
Qin LI
;
Jie BAI
;
Zongxiao DU
- Publication Type:Journal Article
- Keywords:
immune thrombocytopenia;
platelet specific autoantibody;
cytometric bead assay
- From:
International Journal of Laboratory Medicine
2015;(15):2135-2136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the changes and clinical significance of the expression of anti‐GPⅡb/Ⅲa and anti‐GPⅠb/ⅠX on anti‐secreting B cells in patient with thrombocytopenia .Methods Expression of anti‐GPⅡb/Ⅲa and anti‐GPⅠb/ⅠX specific autoantibodies in thrombocytopenia were tested with (CBA) .Results There were significantly more circulating anti‐GPⅠ b/ⅠX and anti‐GPⅡb/Ⅲa antibody‐producing B cells in primary ITP(P<0 .05) for all comparisons .For diagnosing primary ITP ,the an‐ti‐GPⅠb/ⅠX had 43% sensitivity and 89% specificity ,whereas the anti‐GPⅡ b/Ⅲ a had 86% sensitivity and 83% specificity . When two tests were combined ,the sensitivity improved to 90% without a reduction in specificity .Conclusion The assay for detec‐ting anti‐GPⅠb/ⅠX is useful for identifying patients with ITP ,but its utility for diagnosing ITP is inferior to the anti‐GPⅡb/Ⅲa assay .
