Study on evaluation method of pharmacodynamic of Chinese medicine in treating brain injury in vitro
10.3760/cma.j.issn.1673-4246.2015.08.028
- VernacularTitle:抗脑损伤中药药效学的体外评价方法概述
- Author:
Lei LIU
;
Hui ZHAO
;
Lei WANG
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Cell model;
Evaluation method;
Pharmacodynamic of Chinese medicine
- From:
International Journal of Traditional Chinese Medicine
2015;(8):759-762
- CountryChina
- Language:Chinese
-
Abstract:
The literatures on methods of pharmacodynamic of Chinese medicine in treating brain injury in vitro nearly 10 years were collected and summarized. The studies found that evaluated methods of pharmacodynamic of Chinese medicine in treating brain injury in vitro as followed: the experimental methods of anti-brain injury medicine were mainly used in vitro by serum or cerebrospinal fluid pharmacology, the cell models ofβ-amyloid toxicity, low sugar hypoxia, MPP+ toxicity were often used, the indexes of evaluation such as pathology, neuronal apoptosis, brain energy metabolism and oxidative stress of neuronal cells were chosen. When the researchers evaluate the pharmacodynamic of Chinese medicine, the appropriate experimental models and indexes will be selected based on experimental purposes.
