Diagnostic value of N-terminal pro-brain natriuretic peptide and MB isoenzyme of creatine kinase for heart failure in pneumonia children
10.3969/j.issn.1000-3606.2015.08.004
- VernacularTitle:N末端B型钠尿肽原和肌酸激酶同工酶MB对肺炎患儿心力衰竭的诊断价值
- Author:
Shenhua TANG
;
Xiuhong JIA
;
Jianchang LI
;
Xiaomei LI
;
Yanyan ZHANG
- Publication Type:Journal Article
- Keywords:
pneumonia;
heart failure;
N-terminal pro-brain natriuretic peptide;
MB isoenzyme of creatine kinase;
child
- From:
Journal of Clinical Pediatrics
2015;(8):694-697
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the diagnostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) and MB isoenzyme of creatine kinase (CK-MB) for heart failure (HF) in pneumonia children.MethodsThe NT-proBNP and CK-MB were assayed in 132 pneumonia children with HF, 138 pneumonia children without HF and 62 healthy children were recruited into this study. A receiver operating characteristics (ROC) curve and a logistic regression model were employed to assess the diagnostic accuracy of NT-proBNP and CK-MB for HF in pneumonia children.ResultsPneumonia children with HF had higher blood NT-proBNP and CK-MB than those in pneumonia children without HF and healthy controls (P<0.01 for both). Pneumonia children with HF had higher blood NT-proBNP and CK-MB than the pneumonia children without HF. The area under curves (AUCs) of NT-proBNP and CK-MB for HF were 0.85 and 0.72, respectively. The AUC for their combinational usage was 0.87.ConclusionBoth NT-proBNP and CK-MB are effective markers as diagnostic adjuncts for HF in pneumonia children. Combination of NT-proBNP and CK-MB can improve the diagnostic accuracy for HF in pneumonia children.