The preliminary study of diffusion kurtosis imaging in prostate cancer
10.3969/j.issn.1002-1671.2015.08.017
- VernacularTitle:前列腺癌扩散峰度成像的初步研究
- Author:
Qiuying YAO
;
Shiteng SUO
;
Zhiguo ZHUANG
;
Yu FAN
;
Xiaoxi CHEN
;
Lianming WU
;
Jianrong XU
- Publication Type:Journal Article
- Keywords:
diffusion-weighted imaging;
diffusion kurtosis imaging;
prostate cancer
- From:
Journal of Practical Radiology
2015;(8):1301-1304
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility of diffusion kurtosis imaging (DKI)in the diagnosis and aggressiveness assessment of prostate cancer.Methods The MR data with multi-b-value diffusion-weighted imaging (DWI)of 30 male patients with prostate cancer were retrospectively analyzed.D maps and K maps were generated from the DKI model and ADC maps were obtained using the conventional monoexponential model.Differences in the D,K and ADC values between prostate cancer and benign peripheral zone (PZ)tissues,among tumors with different Gleason scores were analyzed.P<0.05 was considered statistical significance.Results ADC and D values were significantly lower in the prostate cancers than in the benign PZs (P <0.001).K values were significantly greater in the prostate cancers than in the benign PZs (P <0.001).ADC,D and K values were different significantly among the tumors with Glea-son scores of 6,7 and ≥8 (P <0.001,P =0.01 5 and P <0.001,respectively).Conclusion The DKI model can better describe the signal intensity attenuation with b values increasing,which is helpful for diagnosing and grading prostate cancer.K value may be used to quantitatively evaluate the complicated microstructure of prostate cancer.
