Study on diagnostic value of CD44 and CD166 in rectal cancer with hepatic me-tastasis
10.3969/j.issn.1000-484X.2015.08.024
- VernacularTitle:CD44和CD166在直肠癌肝转移诊断中的价值研究
- Author:
Zhiying SI
;
Ying JIN
;
Youcai LI
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
Hepatic metastasis;
Tumor;
CD44;
CD166;
Positive expression;
Clinical value
- From:
Chinese Journal of Immunology
2015;(8):1105-1108
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical significance of tumor tissue of patients with liver metastasis of colorectal cancer CD44,CD166 expression.Methods:Retrospective analysis clinical data in our hospital from Octobor 2008 to October 2013,these data from 76 patients with rectal cancer was divided into the test group ( liver metastasis group, n=40 ) and control group ( without liver metastases group, n=36 ) .All of specimens were identified with qualitative immunohistochemical analysis.Observation the positive expression of CD166/CD44, age, sex, clinical stage, invasion depth, lymph node metastasis, Dukes staging, pathological tissue differentiation parameter correlation and the survival rate.Results: In test group,the positive expression of CD44,CD166 groups were respectively 72.50%,85%;in the control group,the positive expression rates of CD44 and CD166 were 36.11%,41.67%.The two groups have significant difference(P<0.05).In test group,expression of CD44,CD166 has no significant difference(P>0.05) with age,gender, histological differentiation.However it showed significant difference with the depth of invasion, Dukes ( P<0.05 ) .In addition,the survival ratio of the test group was significant lower than control group(P<0.05).Conclusion: In rectal cancer,CD166 and CD44 are a hallmark of liver metastasis,rectal cancer,which could determine the process of development.To explore the expression of CD44 and CD166 is helpful to early diagnosis and treatment scheme of rectal cancer.
