Progress Review on Transduction Mechanism of Obese PCOS and IR through Kidney-tonifying, Spleen-invigorating and Phlegm-resolving
10.11842/wst.2015.06.029
- VernacularTitle:补肾健脾化痰法论治肥胖型PCOS伴发IR的信号转导机制研究进展＊
- Author:
Wanjing LI
;
Xiaojuan XU
;
Yinghong HUANG
;
Yanmei ZHONG
;
Lijuan YAO
;
Yunliang HE
- Publication Type:Journal Article
- Keywords:
Obese polycystic ovary syndrome;
insulin resistance;
kidney-tonifying;
spleen-invigorating and phlegm-resolving;
PI-3K/Akt signal pathway;
TNF-α signal pathway;
interactive dialogue
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(6):1285-1289
- CountryChina
- Language:Chinese
-
Abstract:
This paper elaborated the research progress on transduction mechanisms of obese polycystic ovary syndrome (PCOS) and insulin resistance (IR). The action mechanisms of kidney-tonifying, spleen-invigorating and phlegm-resolving in the treatment of obese PCOS and IR were explored. It provided new ideas for the treatment of obese PCOS patients in the clinical practice of traditional Chinese medicine (TCM) gynecology. Literatures on TCM theories and modern signal pathways were used in the analysis of spleen-kidney deficiency and phlegm-dampness retention, which were the key pathogenesis of obese PCOS and IR. The scientific nature of treating obese PCOS and IR from the method of kidney-tonifying, spleen-invigorating and phlegm-resolving was demonstrated. The results showed that the scientific nature of treating obese PCOS and IR from the method of kidney-tonifying, spleen-invigorating and phlegm-resolving was initially demonstrated by the organic combination of TCM and modern medicine theories. It innovatively proposed that the treatment study strategy of transduction molecular mechanism took the interactive dialogue between PI-3K/Akt signal pathway and TNF-α signal pathway as its target. The regulatory role and action mechanism of this method in the treatment of obese PCOS and IR were discussed.
