Protective effects of sodium ferulate and oxymatrine on rats cerebral ischemia-reperfusion injury by reducing oxidative stress
10.3760/cma.j.issn.1673-4246.2015.08.012
- VernacularTitle:阿魏酸钠联合苦参素对脑缺血再灌注模型大鼠脑组织氧化应激的影响
- Author:
Jian XIE
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia-reperfusion injury;
Sodium ferulate;
Oxymatrine;
Rats
- From:
International Journal of Traditional Chinese Medicine
2015;(8):716-719
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effects of Sodium Ferulate (SF) combined with Oxymatrine (OMT) on rats cerebral ischemia-reperfusion injury (CIRI) and its mechanisms.Methods Rats were divided into a sham-operation, a model, a edaravone, a SF, a OMT and a low, a middle, a high dose of combination groups by random number table, with each group contained 12 rats. Edaravone (3 mg/kg), SF (25 mg/kg), OMT (50 mg/kg) and combination (SF 12.5 mg/kg + OMT 25 mg/kg; SF 25 mg/kg + OMT 50 mg/kg; SF 50 mg/kg + OMT 100 mg/kg) were injected intravenously to the rats. Normal saline were injected to rats of the sham-operation and the model groups. One injection was operated for continuous 5 days. At 30 minutes after last administration, CIRI was made on rats except for sham-operation. At 24 hours after reperfusion, rats were sacrificed. Infarcts volumes, superoxide dismutase (SOD) and malondialdehyde (MDA) were measured.Results Infarcts volumes (F=73.183,P<0.01) and MDA contents (F=17.104,P<0.01) were significantly reduced and SOD vitalities (F=11.417,P<0.01) was increased in the SF, OMT and the combination groups. Effects of the combination groups were significantly better than the SF or the OMT groups (P<0.05). Conclusion Combination of SF and OMT had good effects to treat CIRI. The mechanisms were connected with anti-oxidative damages.
