Study on the Preparing and Quality Control for Golden Gel
10.11842/wst.2015.05.031
- VernacularTitle:金黄凝胶制备及质量控制研究*
- Author:
Jianlan TANG
;
Shan ZHANG
;
Chengwei LIU
;
Jun CHEN
;
Gang DING
;
Zhenzhong WANG
;
Wei XIAO
;
Guorong JIANG
;
Rong LU
- Publication Type:Journal Article
- Keywords:
Warter-soluble gel;
modeling process;
stability;
orthogonal test
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(5):1085-1089
- CountryChina
- Language:Chinese
-
Abstract:
This article is aimed to study the optimal process of preparation of Golden water-soluble gel, and to establish its quality control method. Taking the gel forming properties, stability, water loss rate, pH as investigation index, the best extraction process was screened by single factor and orthogonal test design. TLC method was used to identify the product of trichosanthin, rhubarb, and the content of paeoniflorin was determined by HPLC method. The optimal condition of preparation process is to use 1% carbomer as gel matrix, 10% glycerol as humectants, and 0.5%triethanolamine as pH modulators; trichosanthes and rhubarb could be detected by TLC method, with pH range 5.00 - 5.15. The linear range of paeoniflorin was 29.04-945.20μg·mL-1, the average recovery was 98.80%, and RSD was 2.91% (n=9). Golden gel forming process is simple and quality controllable with reliability and good stability.