Effect ofZi-Bu Pi-Yin Recipe on mRNA Expressions of NMDA Receptor in Different Brain Regions of Spleen-yin Deficiency Alzheimer's Disease Model Rats

VernacularTitle:滋补脾阴方药对脾阴虚痴呆大鼠脑内NMDA受体mRNA表达的影响＊
Author: Xiaoyang GONG ; Libin ZHAN ; Hua SUI ; Lina LIANG ; Jian WANG
Publication Type:Journal Article
Keywords: Spleen-yin deficiency Alzheimer's disease; Zi-Bu Pi-Yin recipe; NR1; NR2A; NR2B
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(6):1235-1242
CountryChina
Language:Chinese
Abstract: This study was aimed to observe the effect ofZi-Bu Pi-Yin Recipe (ZBPYR) on the mRNA expressions of NMDA receptor subunits NR1, NR2A, NR2B in different brain regions of spleen-yin deficiency Alzheimer's Disease (AD) model rats. The levels of NR1, NR2A, NR2B mRNA expressions were detected by using RT-PCR method. The results showed that the levels of NR1, NR2A, NR2B mRNA expressions of AD group and spleen-yin deficiency AD group decreased significantly (P < 0.05). The levels of NR1, NR2A, NR2B mRNA expressions of ZBPYR treatment group increased significantly (P < 0.05). It was concluded that the expression levels of NMDAR mRNA in different brain regions of the ZBPYR treatment group increased significantly, which indicated that ZBPYR may up-regulate the protein expressions of NMDAR by increasing the expression levels of NMDAR mRNA, thereby to play the anti-dementia effect.