Advances in Proliferation Model of Vascular Smooth Muscle Cells and Inhibitory Effects and Mechanisms of Chinese Herbal Medicine
10.11842/wst.2015.05.004
- VernacularTitle:血管平滑肌增殖模型及中药抑制作用与机制的研究进展＊
- Author:
Haitao FENG
;
Xiuping CHEN
;
Yitao WANG
- Publication Type:Journal Article
- Keywords:
Smooth muscle cells;
proliferation model;
ox-LDL;
AGEs;
AngⅡ;
high glucose;
TNF-α;
Chinese herbal medicine
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(5):939-944
- CountryChina
- Language:Chinese
-
Abstract:
The proliferation of vascular smooth muscle cells is closely related to the pathogenesis of a variety of diseases, such as atherosclerosis, hypertension, diabetes, vascular restenosis, and etc. A proper model for smooth muscle cell proliferation can be served as an important tool for exploring the molecular mechanisms of smooth muscle cell proliferation and the screening of potential inhibitory agents. Various factors can induce the proliferation of smooth muscle cells with different mechanisms and pathological significance. The ox-LDL, AGEs, angiotensin II (AngⅡ), high glucose, tumor necrosis factor (TNF) and etc. have been successfully applied in the establishment of smooth muscle cell proliferation model. This article summarized the most commonly used models for smooth muscle cell proliferation. The inhibitory effects of Chinese herbal medicine, especially the isolated pure compounds were discussed. It was aimed to provide references for the screening of smooth muscle cells based medications as well as studies on related research and development of Chinese herbal medicine.
