Research Development on Anticancer Mechanisms of Abrin
10.11842/wst.2015.05.005
- VernacularTitle:相思子蛋白抗肿瘤作用机制的研究进展
- Author:
Ying YU
;
Runmei YANG
;
Nannan GAO
- Publication Type:Journal Article
- Keywords:
Abrin;
anticancer mechanism;
cell proliferation;
apoptosis;
immune function
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(5):945-949
- CountryChina
- Language:Chinese
-
Abstract:
Abrin is isolated from abrin seeds (Aburs precatoriusL.), which is a kind of cytotoxic protein. This article reviewed the anticancer effect and mechanisms of Abrin from five aspects in several years, which were the molecular structure and toxicity of Abrin, the characteristics of Abrin in anticancer effect, the role of Abrin in inhibiting cancer cell proliferation, the mechanisms of Abrin induced apoptosis of cancer cells, the anticancer mechanisms of Abrin in enhancing immune function. And the application prospect of Abrin immunotoxin targeted therapy and nano preparation will be expounded in this article. It will be helpful to further research about application on Abrin. It will provide the scientific basis for discovering new drug targets of cancer.