Relationship of different histological classifications of gastric cancer with microvessel density and related factors
10.3969/j.issn.1000-8179.20150394
- VernacularTitle:胃癌不同组织学分型与微血管密度及相关因子的关系
- Author:
Jingfang LV
;
Baocun SUN
;
Huizhi SUN
;
Yanhui ZHANG
;
Junying SUN
;
Xiulan ZHAO
;
Qiang GU
;
Xueyi DONG
;
Na CHE
- Publication Type:Journal Article
- Keywords:
gastric cancer;
Lauren classification;
WHO classification;
MVD;
p53;
MMP-2;
MMP-9;
VEGF;
VEGFR
- From:
Chinese Journal of Clinical Oncology
2015;(15):737-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlations of Lauren classification and world health organization (WHO) classification of gastric cancer (GC) with microvascular density (MVD), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor 1 (VEGFR1), vascular endothelial growth factor receptor 2 (VEGFR2), and p53. Methods:The clinical data of 89 patients with GC were collected. The collected specimens were categorized on the basis of Lauren classification and WHO classification. CD34/periodic acid-Schiff (PAS) double staining was performed to validate MVD. Immunohistochemistry was conducted to investigate the expression levels of MMP-2, MMP-9, VEGF, VEGFR1, VEGFR2, and p53. Results:MVD was not correlated with Lauren classification or WHO classification (P>0.05). Lauren typing was associated with the expression levels of MMP-9, VEGFR1, and p53 (P<0.05). WHO classification was not related to any of the factors (P>0.05). Cox proportional hazards model revealed that Lauren classification and WHO classification were the prognostic factors of overall survival (P<0.05). Conclusion:This research on tumor related factors, angiogenesis, and different classifications of GC may provide new methods to treat this disease.
