New development in the research on FoxO3a and urologic neoplasm
10.3969/j.issn.1000-8179.20150645
- VernacularTitle:FoxO3a与泌尿系肿瘤关系的研究进展
- Author:
Yuejun TIAN
;
Yan TAO
;
Qi GUO
;
Zhiping WANG
;
Mei HONG
- Publication Type:Journal Article
- Keywords:
FoxO3a;
urologic neoplasm;
signal transduction
- From:
Chinese Journal of Clinical Oncology
2015;(15):770-773
- CountryChina
- Language:Chinese
-
Abstract:
The forkhead box O (FoxO) transcription factor family plays an important role in cell functions, including metabo-lism, apoptosis, cellular proliferation, stress reactions, DNA repair, and immune response. As a member of this family, forkhead box O3a (FoxO3a) regulates its target genes by modulating histone modifications, including phosphorylation, acetylation, and methylation. FoxO3a expression is abnormally downregulated in urologic neoplasm. Protein modifications and FoxO3a activity are mainly con-trolled by PI3K/Akt signal pathway and other signaling pathways. FoxO3a is also involved in the initiation, progression, and prognosis of urologic neoplasm. This review focuses on the function of FoxO3a in urologic neoplasm and elucidates the regulatory mechanisms involved. This article will provide novel strategies to clinical diagnosis and drug therapy of urologic neoplasms.
