Study on Antibacterial Activity and Immunomodulation Effect ofRe-Du-Ning Injection
10.11842/wst.2015.05.026
- VernacularTitle:热毒宁注射液抗菌及调节免疫活性作用研究＊
- Author:
Shuai ZHANG
;
Hongmei WANG
;
Xiujuan CHANG
;
Jian CHEN
;
Chunmiao CHEN
;
Jun ZHOU
;
Zhenzhong WANG
;
Wei XIAO
- Publication Type:Journal Article
- Keywords:
Re-Du-Ning injection;
antibacterial;
humoral immunity;
cellular immunity;
non-specific immunity
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(5):1056-1060
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to discuss the antibacterial and immunomodulation effect ofRe-Du-Ning (RDN) injection. Mice were randomly divided into the normal group, model group,Shuang-Huang-Lian (SHL) group (7.8 mL·kg-1), RDN high dose group (20.30 g·kg-1), middle dose group (10.15 g·kg-1), and low dose group (5.08 g·kg-1), in order to observe the death protective effect of mice with bacterial infection on antibacterial experimentin vivo. Mice were randomly divided into the normal group, model group,Xiang-Gu Duo-Tang (XGDT) group (0.19 mg·kg-1), RDN high dose group (20.30 g·kg-1), middle dose group (10.15 g·kg-1), and low dose group (5.08 g·kg-1). The 2, 4-dinitrochlorobenzene was used to induce delayed hypersensitivity. Immunomodulation was observed by the content of serum hemolysin and the carbon particle clearance index. The results showed that the RDN high dose group and middle dose group had antibacterial effect, which reduced the mortality of mice. The RDN high dose, middle dose and low dose group can enhance the phagocytosis of macrophage in immunosuppressive mice, increase the formation of hemolysin, and strengthen delayed hypersensitivity reaction among immunocompromised mice. It was concluded that RDN injection had antibacterial effect. Its immunomodulation effect was through the enhancing of non-specific immunity, humoral immunity and cellular immunity of mice.
