Expression of MKK4 protein in nasopharyngeal carcinoma and their clinical sig-nificances
10.3969/j.issn.1000-484X.2015.09.019
- VernacularTitle:MKK4蛋白在鼻咽癌组织中的表达及临床意义
- Author:
Mingqian LU
;
Qingzhi KONG
;
Xinhua XU
;
Hongda LU
;
Zhongxin LU
;
Chao TAN
;
Bingqing XU
;
Rong GUO
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal carcinoma;
MKK4 protein;
Immunohistochemistry
- From:
Chinese Journal of Immunology
2015;(9):1235-1238
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of MKK 4 protein in the nasopharyngeal carcinoma and its clinical significance.Methods:Immunohistochemical methods were employed to analyze MKK 4 positive expression intensity and positive cells in freshly collected nasopharyngeal carcinoma of both 90nasopharyngeal carcinoma cases and 20 chronic nasopharyngitis control.The clinical pathological characteristic were analyzed.Results:The data obtained by MKK4 immunohistochemistry showed that the MKK 4 positive rate was higher in control group than in the NPC group (95.5%vs 75.6%,P<0.05).The expression of MKK4 was related to tumor differentiation and lymph node metastasis ( P<0.05 ) , but not to gender , age, tumor volum and TNM stage ( P>0.05 ) . Conclusion:Positive rate of MKK4 protein in nasopharyngeal carcinoma tissues is lower than in chronic nasopharyngitis.MKK4 protein expressions in nasopharyngeal carcinoma tissues negatively correlated with lymph node metastasis ,clincal stage ,invasive depth ,and TTP (Time to progression),but not with age,gender,location and tumor volume.
