Relationship between TF,TFPI and severity in patients with diabetic cerebral in-farction
10.3969/j.issn.1000-484X.2015.09.020
- VernacularTitle:糖尿病脑梗死急性期TF、TFPI水平与其病情严重程度的关系
- Author:
Li ZHANG
;
Qing HONG
;
Youyu JIN
;
Haibo CAI
- Publication Type:Journal Article
- Keywords:
Tissue factor;
Tissue factor pathway inhibitor;
Diabetic cerebral infarction;
Severity
- From:
Chinese Journal of Immunology
2015;(9):1239-1241
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between tissue factor (TF),tissue factor pathway inhibitor (TFPI) and the severity in patients with diabetic cerebral infarction.Methods: 226 patients with diabetic cerebral infarction were included into the study,National Institute of Health Stroke Scale ( NIHSS) was used to evaluate the severity of CIS.The single factor analysis and multiple regression analysis were used to explore the relationship between TF , TFPI and the severity.Results: The concentrations of TF,TFPI,TF/TFPI,cholesterol and triglyceride in the NIHSS≤12 group were significantly lower than that in the NIHSS>12 group ( P<0.05);the NIHSS was significantly positive correlate with TF (r=0.354,P=0.012),TFPI (r=0.302,P=0.027),TF/TFPI (r=0.410,P=0.000),cholesterol (r=0.364,P=0.006) and triglycerides (r=0.334,P=0.018);Multiple linear regression analysis showed that the TF , TFPI, TF/TFPI, cholesterol were independent risk factors of the severity in patients with diabetic cerebral infarction.Conclusion:The level of TF and TFPI could reflect the severity in patients with diabetic cerebral infarction according to the NIHSS.
