Evaluation on the efficacy of pamidronate disodium in treatment of osteocarcinoma
- VernacularTitle:帕米膦酸二钠治疗骨转移癌患者的疗效评价
- Author:
Mengxing LIU
;
Tao WU
- Publication Type:Journal Article
- Keywords:
disodium pamidronate;
bone metastasis cancer;
bone pain;
NTx
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):131-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of disodium pamidronate in treatment of bone metastasis cancer .Methods 50 cases of bone metastasis cancer were divided into control group and experimental group according to different medication, 25 cases in each group.Control group was treated by chemotherapy, experimental group was treated on the basis of control group with disodium pamidronate 45 mg+0.9%sodium chloride solution 500 mL, intravenous drip.Pain maintenance time, patient pain grading and serum NTx levels were compared after treatment.ResuIts Compared with control group,pain maintenance time of experimental group was longer(P <0.05),pain level overall score was lower,NTx was lower(P <0.05). ConcIusion Disodium pamidronate can inhibit bone metastasis cancer patients with the degree of pain, reduce the levels of serum NTx.
